The present study was aimed to determine the effect of methanolic extract of S. torvum on isolated strip ileum of overnight fasted rat. S. torvum seeds were extracted with methanol by soxhlet extraction. Cumulative dose response of acetylcholine was taken on student organ bath with a constant dose of S. torvum methanolic extract (STME) 0.4 ml (100 mg/ml). pA2 value was calculated by Schild plot method, then compared with control and treated isolated tissue responses. Methanolic extract increases the contractility of rat ileum as compared to the control rat ileum tissue preparation, therefore pA2 value of atropine on treated tissue is less as compared to pA2 value on control tissue.pA2 value on treated tissue is 7.88 and pA2 value on control tissue is 8.2. From the following results, it was concluded that extract acts as agonist which increases contractile effect of smooth muscle of ileum.
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